Small molecules which reverse DOCK8 KO
Canned Analysis
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General Information
AccessionDCA00022036
TitleSmall molecules which reverse DOCK8 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by DOCK8 KO in the thymic natural killer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20bc6e467bea600fba6aa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorRuta
CREEDS IDgene:2405
Cell Typethymic natural killer cells
Gene Symbol (human)DOCK8
Gene Symbol (mouse)Dock8
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1092004, GSM1092005, GSM1092006
Perturbed SamplesGSM1092001, GSM1092002, GSM1092003
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44814
Gene Expression Omnibus
DOCK8 is critical for the survival and function of NKT cells [DOCK8_CPM_NKT]
7
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