Small molecules which reverse MECP2 KO
Canned Analysis
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General Information
AccessionDCA00022064
TitleSmall molecules which reverse MECP2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MECP2 KO in the brain, motor cortex, layer 5 thick tufted pyramidal neurons cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2071fe467bea600fba49e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2415
Cell Typebrain, motor cortex, layer 5 thick tufted pyramidal neurons
Gene Symbol (human)MECP2
Gene Symbol (mouse)Mecp2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM215865, GSM215866, GSM215867
Perturbed SamplesGSM215868, GSM215869, GSM215870
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8720
Gene Expression Omnibus
Cell type specific expression data from Mecp2 null mice
35
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