Small molecules which mimic MECP2 KO
Canned Analysis
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General Information
AccessionDCA00022067
TitleSmall molecules which mimic MECP2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by MECP2 KO in the brain, cerebellum, Purkinje cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2070ae467bea600fba494
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2417
Cell Typebrain, cerebellum, Purkinje cells
Gene Symbol (human)MECP2
Gene Symbol (mouse)Mecp2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM444379, GSM444380, GSM444381
Perturbed SamplesGSM444382, GSM444383, GSM444384
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8720
Gene Expression Omnibus
Cell type specific expression data from Mecp2 null mice
35
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