Small molecules which mimic FMR1 KO
Canned Analysis
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General Information
AccessionDCA00022071
TitleSmall molecules which mimic FMR1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by FMR1 KO in the blood cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d206f7e467bea600fba48c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2419
Cell Typeblood
Gene Symbol (human)FMR1
Gene Symbol (mouse)Fmr1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM998370, GSM998371, GSM998372, GSM998373, GSM998374
Perturbed SamplesGSM998360, GSM998361, GSM998362, GSM998363, GSM998364
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40630
Gene Expression Omnibus
Divergent dysregulation of gene expression in Fmr1 and Tsc2 knockout mouse models of autism spectrum disorders
21
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