Small molecules which reverse FMR1 KO
Canned Analysis
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General Information
AccessionDCA00022074
TitleSmall molecules which reverse FMR1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by FMR1 KO in the cerebellum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20299e467bea600fba2a2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2420
Cell Typecerebellum
Gene Symbol (human)FMR1
Gene Symbol (mouse)Fmr1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM998375, GSM998376, GSM998377, GSM998378, GSM998379
Perturbed SamplesGSM998365, GSM998366, GSM998367, GSM998368, GSM998369
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40630
Gene Expression Omnibus
Divergent dysregulation of gene expression in Fmr1 and Tsc2 knockout mouse models of autism spectrum disorders
21
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