Small molecules which mimic TSC2 inactivating mutation
Canned Analysis
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General Information
AccessionDCA00022075
TitleSmall molecules which mimic TSC2 inactivating mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TSC2 inactivating mutation in the cerebellum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d238a2e467bea600fbba36
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2482
Cell Typecerebellum
Gene Symbol (human)TSC2
Gene Symbol (mouse)Tsc2
Organismmouse
Perturbation Typeinactivating mutation
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM998389, GSM998390, GSM998391
Perturbed SamplesGSM998383, GSM998384, GSM998385
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE40630
Gene Expression Omnibus
Divergent dysregulation of gene expression in Fmr1 and Tsc2 knockout mouse models of autism spectrum disorders
21
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