Small molecules which reverse CFTR D508 mutation
Canned Analysis
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General Information
AccessionDCA00022084
TitleSmall molecules which reverse CFTR D508 mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CFTR D508 mutation in the rectal mucosal epithelia cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d202bde467bea600fba2b2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2425
Cell Typerectal mucosal epithelia
Gene Symbol (human)CFTR
Gene Symbol (mouse)Cftr
Organismhuman
Perturbation TypeD508 mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM389668, GSM389669, GSM389670, GSM389671, GSM389672, GSM389673, GSM389674, GSM389675, GSM389676, GSM389677, GSM389678, GSM389679, GSM389680
Perturbed SamplesGSM389652, GSM389653, GSM389654, GSM389655, GSM389656, GSM389657, GSM389658, GSM389659, GSM389660, GSM389661, GSM389662, GSM389663, GSM389664, GSM389665, GSM389666, GSM389667
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15568
Gene Expression Omnibus
Cystic fibrosis: rectal epithelia
12
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