Small molecules which reverse THRB d337T mutation - dominant negative
Canned Analysis
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General Information
AccessionDCA00022102
TitleSmall molecules which reverse THRB d337T mutation - dominant negative
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by THRB d337T mutation - dominant negative in the heart cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fbf4e467bea600fb9fb4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2435
Cell Typeheart
Gene Symbol (human)THRB
Gene Symbol (mouse)Thrb
Organismmouse
Perturbation Typed337T mutation - dominant negative
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM67362, GSM67363, GSM67364, GSM67365, GSM67366, GSM67367, GSM67368
Perturbed SamplesGSM67369, GSM67370, GSM67371, GSM67372, GSM67373, GSM67374, GSM67375
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3067
Gene Expression Omnibus
Dominant negative thyroid hormone receptor expression and PPARalpha activation effect on the heart
14
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