Small molecules which mimic SOCS3 KO
Canned Analysis
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General Information
AccessionDCA00022133
TitleSmall molecules which mimic SOCS3 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SOCS3 KO in the Macrophages stimulated for 100 minutes with IL-6 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d214a8e467bea600fbaa90
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDgene:2451
Cell TypeMacrophages stimulated for 100 minutes with IL-6
Gene Symbol (human)SOCS3
Gene Symbol (mouse)Socs3
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM6073, GSM6079, GSM6084
Perturbed SamplesGSM6076, GSM6082, GSM6087
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE411
Gene Expression Omnibus
Macrophage response to IL-6, and SOCS3 effect
14
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