Small molecules which mimic MECP2 heterozygous de novo RTT mutations
Canned Analysis
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General Information
AccessionDCA00022167
TitleSmall molecules which mimic MECP2 heterozygous de novo RTT mutations
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by MECP2 heterozygous de novo RTT mutations in the Superior Frontal Gyrus cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d211c8e467bea600fba950
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2473
Cell TypeSuperior Frontal Gyrus
Gene Symbol (human)MECP2
Gene Symbol (mouse)Mecp2
Organismhuman
Perturbation Typeheterozygous de novo RTT mutations
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM160306, GSM160308, GSM160310
Perturbed SamplesGSM160307, GSM160309, GSM160311
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6955
Gene Expression Omnibus
Rett syndrome: brain frontal cortex
12
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