Small molecules which reverse FH Heterozygous germline mutations
Canned Analysis
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General Information
AccessionDCA00022210
TitleSmall molecules which reverse FH Heterozygous germline mutations
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by FH Heterozygous germline mutations in the uterine fibroid and Myometrium cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2388ae467bea600fbba2c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2489
Cell Typeuterine fibroid and Myometrium
Gene Symbol (human)FH
Gene Symbol (mouse)Fh1
Organismhuman
Perturbation TypeHeterozygous germline mutations
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM52661, GSM52662, GSM52663, GSM52664, GSM52665, GSM52666, GSM52667, GSM52668, GSM52669, GSM52670, GSM52671
Perturbed SamplesGSM38689, GSM38690, GSM38691, GSM38692, GSM38693, GSM38694, GSM38695
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2724
Gene Expression Omnibus
Uterine fibroids with mutated fumarate hydratase (I)
12
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