Small molecules which reverse IRF1 OE
Canned Analysis
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General Information
AccessionDCA00022216
TitleSmall molecules which reverse IRF1 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRF1 OE in the Huh-7 human hepatoma cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2124ce467bea600fba98a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:2502
Cell TypeHuh-7 human hepatoma cells
Gene Symbol (human)IRF1
Gene Symbol (mouse)Irf1
Organismhuman
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM659573, GSM659574, GSM659575
Perturbed SamplesGSM659576, GSM659577, GSM659578
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE26817
Gene Expression Omnibus
Impact of IRF1 on transcriptome changes in Huh-7 human hepatoma cells and STAT1-deficient human fibroblasts
7
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