Small molecules which reverse NOTCH1 OE
Canned Analysis
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General Information
AccessionDCA00022262
TitleSmall molecules which reverse NOTCH1 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NOTCH1 OE in the CD4+/8+ cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d224eee467bea600fbb182
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDgene:2530
Cell TypeCD4+/8+ cells
Gene Symbol (human)NOTCH1
Gene Symbol (mouse)Notch1
Organismmouse
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM850941, GSM850942
Perturbed SamplesGSM850943, GSM850944
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE34554
Gene Expression Omnibus
Notch1 overexpression model of T-cell acute lymphoblastic leukemia: double positive CD4+/8+ cells
7
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