Small molecules which reverse NOTCH1 Reactivation (WASHOUT - 2 Hours)
Canned Analysis
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General Information
AccessionDCA00022324
TitleSmall molecules which reverse NOTCH1 Reactivation (WASHOUT - 2 Hours)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NOTCH1 Reactivation (WASHOUT - 2 Hours) in the CUTLL1 DN-MAML transduced (T-lymphoblastic leukemia) cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2398de467bea600fbba9e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2571
Cell TypeCUTLL1 DN-MAML transduced (T-lymphoblastic leukemia) cell line
Gene Symbol (human)NOTCH1
Gene Symbol (mouse)Notch1
Organismhuman
Perturbation TypeReactivation (WASHOUT - 2 Hours)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM731537, GSM731538, GSM731539
Perturbed SamplesGSM731540, GSM731541, GSM731542
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29544
Gene Expression Omnibus
Notch-on and Notch-off effects on T-lymphoblastic leukemia cell line CUTLL1: time course
35
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