Small molecules which mimic NFKB1 Inactivation (IKK Inhibition)
Canned Analysis
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General Information
AccessionDCA00022333
TitleSmall molecules which mimic NFKB1 Inactivation (IKK Inhibition)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by NFKB1 Inactivation (IKK Inhibition) in the HPB-ALL (Leukemia cell line) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23978e467bea600fbba94
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2577
Cell TypeHPB-ALL (Leukemia cell line)
Gene Symbol (human)NFKB1
Gene Symbol (mouse)Nfkb1
Organismhuman
Perturbation TypeInactivation (IKK Inhibition)
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM542405, GSM542406
Perturbed SamplesGSM542407, GSM542408
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20667
Gene Expression Omnibus
NF-kB inactivation effect on T-ALL1 cell lines
35
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