Small molecules which reverse ATXN1 Knock-in
Canned Analysis
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General Information
AccessionDCA00022344
TitleSmall molecules which reverse ATXN1 Knock-in
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ATXN1 Knock-in in the Forebrain tissue - 12 weeks of age cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f456e467bea600fb9c9c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:261
Cell TypeForebrain tissue - 12 weeks of age
Gene Symbol (human)ATXN1
Gene Symbol (mouse)Atxn1
Organismmouse
Perturbation TypeKnock-in
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM53359, GSM53360
Perturbed SamplesGSM53357, GSM53358
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2867
Gene Expression Omnibus
CAG repeat knock-in model of spinocerebellar ataxia type 1 progression
28
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