Small molecules which mimic SIRT7 KO
Canned Analysis
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General Information
AccessionDCA00022345
TitleSmall molecules which mimic SIRT7 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SIRT7 KO in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1efeee467bea600fb9ab2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDgene:2580
Cell Typeliver
Gene Symbol (human)SIRT7
Gene Symbol (mouse)Sirt7
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1213632, GSM1213633, GSM1213634
Perturbed SamplesGSM1213635, GSM1213636, GSM1213637
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50076
Gene Expression Omnibus
SIRT7 suppresses tumorigenesis by attenuating MYC activity
7
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