Small molecules which mimic PTEN KO
Canned Analysis
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General Information
AccessionDCA00022349
TitleSmall molecules which mimic PTEN KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PTEN KO in the Regulatory T cells (Treg) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1efffe467bea600fb9aba
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:2582
Cell TypeRegulatory T cells (Treg)
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1554125, GSM1554126, GSM1554127
Perturbed SamplesGSM1554128, GSM1554129, GSM1554130
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63625
Gene Expression Omnibus
Regulatory T cells require the phosphatase PTEN to restrain type 1 and follicular helper T-cell responses
7
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