Small molecules which mimic BCL2 OE
Canned Analysis
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General Information
AccessionDCA00022359
TitleSmall molecules which mimic BCL2 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by BCL2 OE in the Tissue: Spleen Type:6 hours after cecal ligation and puncture (CLP) Strain: C57BL/6 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f572e467bea600fb9d16
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2590
Cell TypeTissue: Spleen Type:6 hours after cecal ligation and puncture (CLP) Strain: C57BL/6
Gene Symbol (human)BCL2
Gene Symbol (mouse)Bcl2
Organismmouse
Perturbation TypeOE
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM135730, GSM135737, GSM135738, GSM135739, GSM135740, GSM135741
Perturbed SamplesGSM135725, GSM135726, GSM135727, GSM135728, GSM135729
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE5811
Gene Expression Omnibus
Surviving Sepsis: bcl-2 Overexpression Modulates Splenocyte Transcriptional Responses in vivo
28
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