Small molecules which mimic NOTCH3 KO
Canned Analysis
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General Information
AccessionDCA00022425
TitleSmall molecules which mimic NOTCH3 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by NOTCH3 KO in the Cerebral microvascular fragments cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21598e467bea600fbaaf8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorCarolet
CREEDS IDgene:2648
Cell TypeCerebral microvascular fragments
Gene Symbol (human)NOTCH3
Gene Symbol (mouse)Notch3
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1331539, GSM1331540, GSM1331541
Perturbed SamplesGSM1331545, GSM1331546, GSM1331547
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55203
Gene Expression Omnibus
Gene expression changes in brain vascularture in Notch3 knockout mice
7
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