Small molecules which reverse GATA1 DeltaN mutation
Canned Analysis
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General Information
AccessionDCA00022440
TitleSmall molecules which reverse GATA1 DeltaN mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by GATA1 DeltaN mutation in the megacariocyte progenitors cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fc3de467bea600fb9fd4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:980
Cell Typemegacariocyte progenitors
Gene Symbol (human)GATA1
Gene Symbol (mouse)Gata1
Organismmouse
Perturbation TypeDeltaN mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM45790, GSM45791
Perturbed SamplesGSM45792, GSM45793
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2433
Gene Expression Omnibus
GATA-1 variant role in Down syndrome megakaryocytic leukemias
28
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