Small molecules which reverse PDE6B RD1 mutation
Canned Analysis
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General Information
AccessionDCA00022470
TitleSmall molecules which reverse PDE6B RD1 mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PDE6B RD1 mutation in the retina (postnatal day 6) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20c18e467bea600fba6ce
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2676
Cell Typeretina (postnatal day 6)
Gene Symbol (human)PDE6B
Gene Symbol (mouse)Pde6b
Organismmouse
Perturbation TypeRD1 mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1024811, GSM1024812, GSM1024813, GSM1024814
Perturbed SamplesGSM1024827, GSM1024828, GSM1024829, GSM1024830
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE41821
Gene Expression Omnibus
rd1 model of retinal degeneration: time course
35
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