Small molecules which reverse RB1 KO
Canned Analysis
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General Information
AccessionDCA00022488
TitleSmall molecules which reverse RB1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RB1 KO in the testicle cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22478e467bea600fbb14e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDgene:2685
Cell Typetesticle
Gene Symbol (human)RB1
Gene Symbol (mouse)Rb1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM553675, GSM553680, GSM553681, GSM553684, GSM553686
Perturbed SamplesGSM553676, GSM553679, GSM553683, GSM553685
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22234
Gene Expression Omnibus
Role of retinoblastoma protein (Rb) in mouse Sertoli cells function
7
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