Small molecules which reverse CYFIP1 OE
Canned Analysis
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General Information
AccessionDCA00022492
TitleSmall molecules which reverse CYFIP1 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CYFIP1 OE in the SY5Y cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22804e467bea600fbb2e2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormauroccm
CREEDS IDgene:2690
Cell TypeSY5Y
Gene Symbol (human)CYFIP1
Gene Symbol (mouse)Cyfip1
Organismmouse
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1003284, GSM1003286, GSM1003287
Perturbed SamplesGSM1003283, GSM1003285, GSM1003288
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40852
Gene Expression Omnibus
Overexpression of disease-associated CYFIP1 alters cellular and synaptic morphology through mTOR dysregulation of mTOR signaling
7
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