Small molecules which mimic MS4A1 blockade of gene product (CD20)
Canned Analysis
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General Information
AccessionDCA00022493
TitleSmall molecules which mimic MS4A1 blockade of gene product (CD20)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by MS4A1 blockade of gene product (CD20) in the Rheumatoid arthritic synovium cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2169ee467bea600fbab6c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:2692
Cell TypeRheumatoid arthritic synovium
Gene Symbol (human)MS4A1
Gene Symbol (mouse)Ms4a1
Organismhuman
Perturbation Typeblockade of gene product (CD20)
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM607508, GSM609031, GSM609033, GSM609035, GSM609037, GSM609386, GSM609388, GSM609390, GSM609392, GSM609394, GSM609396, GSM609398
Perturbed SamplesGSM607509, GSM609032, GSM609034, GSM609036, GSM609038, GSM609387, GSM609389, GSM609391, GSM609393, GSM609395, GSM609397, GSM609399
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24742
Gene Expression Omnibus
Rheumatoid arthritic synovium response to rituximab
12
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