Small molecules which mimic NOTCH2 KO
Canned Analysis
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General Information
AccessionDCA00022607
TitleSmall molecules which mimic NOTCH2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by NOTCH2 KO in the spleen CD11b Dendritic cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20261e467bea600fba288
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKathaLahl
CREEDS IDgene:2768
Cell Typespleen CD11b Dendritic cells
Gene Symbol (human)NOTCH2
Gene Symbol (mouse)Notch2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1111857, GSM1111859, GSM1111861
Perturbed SamplesGSM1111851, GSM1111853, GSM1111855
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45681
Gene Expression Omnibus
Microarray analysis of WT and Notch2-deficient classical DC subsets
7
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