Small molecules which mimic RB1 KO
Canned Analysis
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General Information
AccessionDCA00022729
TitleSmall molecules which mimic RB1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by RB1 KO in the spleen Ter19+CD71 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fdbae467bea600fba078
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorTolen
CREEDS IDgene:2829
Cell Typespleen Ter19+CD71
Gene Symbol (human)RB1
Gene Symbol (mouse)Rb1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1260396, GSM1260397, GSM1260398
Perturbed SamplesGSM1260402, GSM1260403, GSM1260404
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE52157
Gene Expression Omnibus
Expression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
14
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