Small molecules which reverse SOX10 KO
Canned Analysis
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General Information
AccessionDCA00022750
TitleSmall molecules which reverse SOX10 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SOX10 KO in the Schwannoma cell line. NB: This is actually a rat dataset, but I "chose" mouse because mouse is more similar to rats than man and there was no drop down option for Rattus norvegicus. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22c08e467bea600fbb4aa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortpaunesku
CREEDS IDgene:284
Cell TypeSchwannoma cell line. NB: This is actually a rat dataset, but I "chose" mouse because mouse is more similar to rats than man and there was no drop down option for Rattus norvegicus.
Gene Symbol (human)SOX10
Gene Symbol (mouse)Sox10
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM303510, GSM303512
Perturbed SamplesGSM303507, GSM303511
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE12007
Gene Expression Omnibus
Sox10 depletion effect on Schwannoma cell line
7
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