Small molecules which mimic DNMT1 KO
Canned Analysis
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General Information
AccessionDCA00022763
TitleSmall molecules which mimic DNMT1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by DNMT1 KO in the HCT-116 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20cade467bea600fba710
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsara
CREEDS IDgene:2851
Cell TypeHCT-116
Gene Symbol (human)DNMT1
Gene Symbol (mouse)Dnmt1
Organismhuman
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM85452, GSM85453, GSM85454
Perturbed SamplesGSM85457, GSM85458, GSM85459
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3699
Gene Expression Omnibus
DNA-Methyltransferases (DNMT) knockouts
14
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