Small molecules which reverse RPS6KA3 KO
Canned Analysis
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General Information
AccessionDCA00022840
TitleSmall molecules which reverse RPS6KA3 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RPS6KA3 KO in the primary murine fibroblast-like synoviocytes (FLS) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22605e467bea600fbb1fe
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2894
Cell Typeprimary murine fibroblast-like synoviocytes (FLS)
Gene Symbol (human)RPS6KA3
Gene Symbol (mouse)Rps6ka3
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1279903, GSM1279904, GSM1279905
Perturbed SamplesGSM1279900, GSM1279901, GSM1279902
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52992
Gene Expression Omnibus
Ribosomal S6 kinase 2 deficiency effect on TNF- transgenic model of inflammatory arthritis: fibroblast-like synoviocytes
7
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