Small molecules which reverse SPDEF KD
Canned Analysis
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General Information
AccessionDCA00022842
TitleSmall molecules which reverse SPDEF KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SPDEF KD in the MCF-7 BREAST CANCER cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d217cee467bea600fbabf6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2897
Cell TypeMCF-7 BREAST CANCER cell line
Gene Symbol (human)SPDEF
Gene Symbol (mouse)Spdef
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1187094, GSM1187095, GSM1187096, GSM1187097, GSM1187098, GSM1187099
Perturbed SamplesGSM1187106, GSM1187107, GSM1187108, GSM1187109, GSM1187110, GSM1187111
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE48928
Gene Expression Omnibus
Knockdown of breast cancer master regulators: siRNA targeting PTTG1 and SPDEF in MCF-7 cells.
7
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