Small molecules which reverse MAT1A KO
Canned Analysis
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General Information
AccessionDCA00022874
TitleSmall molecules which reverse MAT1A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MAT1A KO in the liver (3 months) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e98e467bea600fba7ee
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2910
Cell Typeliver (3 months)
Gene Symbol (human)MAT1A
Gene Symbol (mouse)Mat1a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1538281, GSM1538282, GSM1538283, GSM1538284, GSM1538285
Perturbed SamplesGSM1538276, GSM1538277, GSM1538278, GSM1538279, GSM1538280
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63027
Gene Expression Omnibus
Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinom...
28
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