Small molecules which reverse PDE10A druginhibition
Canned Analysis
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General Information
AccessionDCA00022878
TitleSmall molecules which reverse PDE10A druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PDE10A druginhibition in the striatum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20c0fe467bea600fba6ca
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorlrallison
CREEDS IDgene:2914
Cell Typestriatum
Gene Symbol (human)PDE10A
Gene Symbol (mouse)Pde10a
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM992511, GSM992512, GSM992513, GSM992514, GSM992515
Perturbed SamplesGSM992516, GSM992517, GSM992518, GSM992519, GSM992520
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40377
Gene Expression Omnibus
Chronic suppression of phosphodiesterase 10A effect on striatum and hippocampus
28
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