Small molecules which reverse PDE10A KO
Canned Analysis
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General Information
AccessionDCA00022882
TitleSmall molecules which reverse PDE10A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PDE10A KO in the striatum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20ad4e467bea600fba63e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorantons
CREEDS IDgene:318
Cell Typestriatum
Gene Symbol (human)PDE10A
Gene Symbol (mouse)Pde10a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM992511, GSM992512, GSM992513, GSM992514, GSM992515
Perturbed SamplesGSM992502, GSM992503, GSM992504, GSM992505, GSM992506
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40377
Gene Expression Omnibus
Chronic suppression of phosphodiesterase 10A effect on striatum and hippocampus
28
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