Small molecules which reverse TERC KD
Canned Analysis
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General Information
AccessionDCA00022886
TitleSmall molecules which reverse TERC KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TERC KD in the PMSCs cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20bfce467bea600fba6c2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorApozar
CREEDS IDgene:2917
Cell TypePMSCs
Gene Symbol (human)TERC
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1563034, GSM1563035, GSM1563036, GSM1563037, GSM1563038, GSM1563039
Perturbed SamplesGSM1563040, GSM1563041, GSM1563042
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE64023
Gene Expression Omnibus
Knockdown of TERC with siRNA in normal bone marrow stromal cells (BMSCs) recapitulates the defective BMSC phenotype in patients with telomere biology ...
7
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