Small molecules which mimic MAT1A KO
Canned Analysis
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General Information
AccessionDCA00022911
TitleSmall molecules which mimic MAT1A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by MAT1A KO in the Liver tumoral tissue (having hepatocellular carcinoma) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21710e467bea600fbaba0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2941
Cell TypeLiver tumoral tissue (having hepatocellular carcinoma)
Gene Symbol (human)MAT1A
Gene Symbol (mouse)Mat1a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1539797, GSM1539798, GSM1539799, GSM1539800, GSM1539801
Perturbed SamplesGSM1539807, GSM1539808, GSM1539809, GSM1539810, GSM1539811
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63062
Gene Expression Omnibus
Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinom...
14
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