Small molecules which mimic PKD1 KO
Canned Analysis
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General Information
AccessionDCA00022917
TitleSmall molecules which mimic PKD1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PKD1 KO in the kidney cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21865e467bea600fbac38
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorlrallison
CREEDS IDgene:2945
Cell Typekidney
Gene Symbol (human)PKD1
Gene Symbol (mouse)Pkd1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM600319, GSM600320, GSM600321
Perturbed SamplesGSM600322, GSM600323, GSM600324
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24352
Gene Expression Omnibus
Systems biology approach to identify transcriptional reprogramming and microRNA targets during the progression of Polycystic Kidney Disease
14
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