Small molecules which reverse PKD1 KO
Canned Analysis
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General Information
AccessionDCA00022920
TitleSmall molecules which reverse PKD1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PKD1 KO in the kidney cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21904e467bea600fbac7e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorlrallison
CREEDS IDgene:2946
Cell Typekidney
Gene Symbol (human)PKD1
Gene Symbol (mouse)Pkd1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM600325, GSM600326, GSM600327
Perturbed SamplesGSM600328, GSM600329, GSM600330
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24352
Gene Expression Omnibus
Systems biology approach to identify transcriptional reprogramming and microRNA targets during the progression of Polycystic Kidney Disease
14
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