Small molecules which mimic SOX2 KO
Canned Analysis
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General Information
AccessionDCA00022939
TitleSmall molecules which mimic SOX2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SOX2 KO in the NTera-2 human embryonal carcinoma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d226bfe467bea600fbb250
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2957
Cell TypeNTera-2 human embryonal carcinoma cell line
Gene Symbol (human)SOX2
Gene Symbol (mouse)Sox2
Organismhuman
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1431072, GSM1431073, GSM1431074
Perturbed SamplesGSM1431075, GSM1431076, GSM1431077
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE59234
Gene Expression Omnibus
Gene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines
14
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