Small molecules which reverse PTEN DELETION
Canned Analysis
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General Information
AccessionDCA00022950
TitleSmall molecules which reverse PTEN DELETION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PTEN DELETION in the HCT116 colon cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21a87e467bea600fbad26
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:86
Cell TypeHCT116 colon cancer cells
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismhuman
Perturbation TypeDELETION
None{u'vals': [0.0689169531755, 0.0676316981893, -0.0633653327081, 0.0567367887388, -0.0545367495676, -0.0509662365145, -0.0503234479057, 0.0490252904174, 0.0483404070614, 0.0474360690326, 0.0473621976653, 0.0469180839963, -0.0462277932524, -0.0453646682587,
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM144202, GSM144203
Perturbed SamplesGSM144204, GSM144205, GSM144206
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6263
Gene Expression Omnibus
PTEN deletion mutation effect on colon cancer cells
14
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