Small molecules which reverse HTT Knock-in
Canned Analysis
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General Information
AccessionDCA00022952
TitleSmall molecules which reverse HTT Knock-in
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTT Knock-in in the striatum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f6f1e467bea600fb9dc0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorlrallison
CREEDS IDgene:2962
Cell Typestriatum
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation TypeKnock-in
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM229435, GSM229436, GSM229437
Perturbed SamplesGSM229438, GSM229439, GSM229440
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE19780
Gene Expression Omnibus
HdhQ111 knock-in model of Huntington's disease: striatum and cerebellum
24
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