Small molecules which mimic HTT knock-in
Canned Analysis
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General Information
AccessionDCA00022953
TitleSmall molecules which mimic HTT knock-in
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by HTT knock-in in the tissue-specific / cerebellum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d212aee467bea600fba9b4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormtahay
CREEDS IDgene:817
Cell Typetissue-specific / cerebellum
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation Typeknock-in
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM229456, GSM229457, GSM229458
Perturbed SamplesGSM229459, GSM229460, GSM229461
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19780
Gene Expression Omnibus
HdhQ111 knock-in model of Huntington's disease: striatum and cerebellum
24
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