Small molecules which mimic IKBKB expression of a constitutively active allele of the IÎ&ord
Canned Analysis
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General Information
AccessionDCA00022961
TitleSmall molecules which mimic IKBKB expression of a constitutively active allele of the IÎ&ord
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by IKBKB expression of a constitutively active allele of the IÎ&ord in the Ramos cells; cell type: human Burkitt lymphoma; dsmz no.: ACC 603 origin: established from the ascitic fluid of a 3-year-old boy with American-type Burkitt lymphoma in 1972; cells were described to be EBV-negative but EBV infectible, to carry the (8;14) translocation and p53 mutations cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21926e467bea600fbac8c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2974
Cell TypeRamos cells; cell type: human Burkitt lymphoma; dsmz no.: ACC 603 origin: established from the ascitic fluid of a 3-year-old boy with American-type Burkitt lymphoma in 1972; cells were described to be EBV-negative but EBV infectible, to carry the (8;14) t
Gene Symbol (human)IKBKB
Gene Symbol (mouse)Ikbkb
Organismhuman
Perturbation Typeexpression of a constitutively active allele of the IÎ&ord
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM428956, GSM428957, GSM428958
Perturbed SamplesGSM428959, GSM428960, GSM428961
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17129
Gene Expression Omnibus
The IKK2/NF-kB-pathway suppresses MYC-induced lymphomagenesis
7
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