Small molecules which mimic KDM6B KD
Canned Analysis
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General Information
AccessionDCA00022981
TitleSmall molecules which mimic KDM6B KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by KDM6B KD in the BxPC3 pancreatic ductal adenocarcinoma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21ce9e467bea600fbae04
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2984
Cell TypeBxPC3 pancreatic ductal adenocarcinoma cell line
Gene Symbol (human)KDM6B
Gene Symbol (mouse)Kdm6b
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM697413, GSM697414, GSM697415
Perturbed SamplesGSM697416, GSM697417, GSM697418
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE28155
Gene Expression Omnibus
Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBP
7
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