Small molecules which reverse IRF8 KO
Canned Analysis
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General Information
AccessionDCA00023002
TitleSmall molecules which reverse IRF8 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRF8 KO in the Spleen (marginal zone B) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22f58e467bea600fbb61e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:2997
Cell TypeSpleen (marginal zone B)
Gene Symbol (human)IRF8
Gene Symbol (mouse)Irf8
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM613485, GSM613486, GSM613487, GSM613488, GSM613489, GSM613490
Perturbed SamplesGSM613491, GSM613492, GSM613493, GSM613494, GSM613495, GSM613496
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24972
Gene Expression Omnibus
Gene expression profiling of spleen marginal zone B cells and spleen follicular B cells in IRF8 conditional KO mice
14
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