Small molecules which reverse IRF8 KO
Canned Analysis
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General Information
AccessionDCA00023004
TitleSmall molecules which reverse IRF8 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRF8 KO in the Spleen (folicular B) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2228fe467bea600fbb07a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:2998
Cell TypeSpleen (folicular B)
Gene Symbol (human)IRF8
Gene Symbol (mouse)Irf8
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM613497, GSM613498, GSM613499, GSM613500, GSM613501, GSM613502
Perturbed SamplesGSM613503, GSM613504, GSM613505, GSM613506, GSM613507, GSM613508
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE24972
Gene Expression Omnibus
Gene expression profiling of spleen marginal zone B cells and spleen follicular B cells in IRF8 conditional KO mice
14
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