Small molecules which mimic LRP5 KO
Canned Analysis
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General Information
AccessionDCA00023081
TitleSmall molecules which mimic LRP5 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by LRP5 KO in the osteoblasts (7 days) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20c5ce467bea600fba6ec
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:3042
Cell Typeosteoblasts (7 days)
Gene Symbol (human)LRP5
Gene Symbol (mouse)Lrp5
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1348211, GSM1348213, GSM1348215, GSM1348217
Perturbed SamplesGSM1348210, GSM1348212, GSM1348214, GSM1348216
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE55900
Gene Expression Omnibus
Low-density lipoprotein receptor-5 contributes to whole body metabolism by regulating fatty acid metabolism in the osteoblast
7
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