Small molecules which reverse TP53 Mutation
Canned Analysis
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General Information
AccessionDCA00023086
TitleSmall molecules which reverse TP53 Mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TP53 Mutation in the Colorectal cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20c44e467bea600fba6e2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgregmicrotask
CREEDS IDgene:3046
Cell TypeColorectal
Gene Symbol (human)TP53
Gene Symbol (mouse)Trp53
Organismhuman
Perturbation TypeMutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM671377, GSM671378, GSM671379
Perturbed SamplesGSM671382, GSM671383, GSM671384
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27157
Gene Expression Omnibus
p53 mutations in microsatellite-stable, stage III colorectal cancer
7
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