Small molecules which reverse IFNAR1 Stimulation of gene product
Canned Analysis
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General Information
AccessionDCA00023128
TitleSmall molecules which reverse IFNAR1 Stimulation of gene product
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IFNAR1 Stimulation of gene product in the Analysis of PBMCs from patients with clinically isolated syndrome suggestive of multiple sclerosis (CIS) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20345e467bea600fba2ee
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:3061
Cell TypeAnalysis of PBMCs from patients with clinically isolated syndrome suggestive of multiple sclerosis (CIS)
Gene Symbol (human)IFNAR1
Gene Symbol (mouse)Ifnar1
Organismhuman
Perturbation TypeStimulation of gene product
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1299335, GSM1299337, GSM1299339, GSM1299341, GSM1299343, GSM1299345
Perturbed SamplesGSM1299336, GSM1299338, GSM1299340, GSM1299342, GSM1299344, GSM1299346
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE53716
Gene Expression Omnibus
IFN-1a in vivo treatment effect on CIS multiple sclerosis patients: peripheral blood mononuclear cells
7
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