Small molecules which reverse PAX6 KO
Canned Analysis
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General Information
AccessionDCA00023168
TitleSmall molecules which reverse PAX6 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PAX6 KO in the distal retinal progenitor cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20658e467bea600fba446
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:3098
Cell Typedistal retinal progenitor cells
Gene Symbol (human)PAX6
Gene Symbol (mouse)Pax6
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1097873, GSM1097874, GSM1097875
Perturbed SamplesGSM1097876, GSM1097877, GSM1097878
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45143
Gene Expression Omnibus
Pax6 is required for normal cell cycle exit and the differentiation kinetics of retinal progenitor cells.
7
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